HCID 53764590, compound → HCID 54677766, compound

HRID 1757095Notes

Reaction equation

HRID 1757095 reaction equation
[O:1]=[C:2]([NH:8][C:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=1[C:15]([O:17]CC)=O)[CH2:3][C:4]([O:6][CH3:7])=[O:5].O=C(NC1CCCCC=1C(OC)=O)CC(OC)=O>>[OH:17][C:15]1[C:10]2[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=2[NH:8][C:2](=[O:1])[C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 53764590HCID 53764590, compoundHCID 54067855HCID 54067855, compound

Product 1

HCID 54677766HCID 54677766, compound

Procedure

Using the general method of Example 1 Part D, a mixture of methyl 3-oxo-3-[(2-ethoxycarbonylcyclohexen-1-yl)amino]propanoate and methyl 3-oxo-3-[(2-methoxycarbonylcyclohexen-1-yl)amino]propanoate (43.2 g, 0.16 mole) was cyclized to provide 35.5 g of methyl 1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxoquinoline-3-carboxylate as an off white solid.

Sources & evidence

ORD record
ord-5cea378a747540378bb1bb95b2a184b5
Source dataset
uspto-grants-1995_08
Patent number
US05444065

Reaction notes

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