Thionyl Chloride → HCID 19973449, compound

HRID 1757114Notes

Reaction equation

HRID 1757114 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, compound

Product 1

HCID 19973449HCID 19973449, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

6.80 g of the 2-methylimidazo[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2-methylimidazo[1,2-a]pyridine hydrochloride was obtained as a brown oil.

Workup

  1. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-26de46e450de4893b074045faa784f42
Source dataset
uspto-grants-1995_08
Patent number
US05444066

Reaction notes

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