HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → Z-Leu-Phe-CO2Bu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Z-Leu-phe-OH | HCID 7408339 | — |
| Reactant | Z-Leu-Phe-CO2Et | HCID 131719097 | — |
| Reactant | Sodium butyloxide | HCID 131719098 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-Leu-Phe-CO2Bu | HCID 131719096 | 43% |
Reaction Steps
This compound was prepared from Z-Leu-Phe-OH and butyl oxalyl chloride in 43% yield by the procedure described for the synthesis of Z-Leu-Phe-CO2Et, except that butyl oxalyl chloride was used in place of ethyl oxalyl chloride and sodium butyloxide in butanol was used for enol ester hydrolysis. Single spot on TLC, Rf =0.54 (CHCl3 :CH3OH=50:1) MS(FAB) m/e=497 (m+1), 1H NMR (CDCl3) ok.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444042 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-801e518cc01e455f9577de8bd85c0d8f |
| Source note | uspto-grants-1995_08 |