HCID 19389968, compound → HCID 19389970, compound

Participants

Reaction Steps

To a suspension of 172 mg (0.00452 mol) of lithium aluminum hydride in 6 mL of THY at 0° C. was added portion-wise 500 mg (0.00226 mol) of the product of Step B. The mixture was refluxed overnight. EtOAc was carefully added to quench excess hydride and 50% aqueous NaOH added. The mixture was extracted with EtOAc and the EtOAc extract washed with brine. It was dried (MgSO4) and concentrated to give an oil which solidified on standing to give 390 mg of a tan solid: mp 89°-95.6° C. 1H NMR (DMSO-d6) d 7.422 (d, 1H), 6.70 (d, 1H), 6.95 (s, 1H), 3.690 (s, 3H), 3.20-3.40 (m, 3H), 2.70 (t, 2H), 2.0-2.20 (m. 2H), 1.70 (m, 2H).

Provenance & Evidence