HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 3-[(2-chlorophenyl)methyl]-2-n-butyl-N-benzylhistidine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 54253690 | HCID 54253690 | — |
| Product | 3-[(2-chlorophenyl)methyl]-2-n-butyl-N-benzylhistidine ethyl ester | HCID 54048955 | — |
| Product | HCID 54567190 | HCID 54567190 | — |
Reaction Steps
The title compound is prepared by reductive alkylation of 2-n-butyl-3-(2-chlorophenyl)methylhistidine ethyl ester with benzaldehyde in the presence of sodium cyanoborohydride to give 3-[(2-chlorophenyl)methyl]-2-n-butyl-N-benzylhistidine ethyl ester. Hydrolysis of the ester group is accomplished according to Example 2 (iii) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444081 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-729140e9aee84c428bc1edacef948946 |
| Source note | uspto-grants-1995_08 |