Methanol → HCID 19390069, compound

Participants

Reaction Conditions

Reaction Steps

30 g (0.136M) of the pyrrolidone (9) was treated with Triton B (60 ml of a 40% methanol solution in 400 ml of benzene. Benzene was distilled off in vacuo, and 400 ml of benzene was again added to the residue. This procedure was repeated three times, and 25.31 g of 3,4-dimethoxybenzyl chloride was added thereto at room temperature. The mixture was stirred at 60° C. for 6 hr, and water was added to the reaction mixture. The resultant organic phase was separated and washed twice with water and once with a saturated saline solution. The organic phase was dried over anhydrous sodium sulfate, and the solvent was distilled off in vacuo. The residue was recrystallized from ethanol to prepare 41.54 g (yield: 82%) of the intended product.

Provenance & Evidence