Hydrochloric Acid → HCID 19390113, compound

Participants

Reaction Conditions

Reaction Steps

200 ml of a solution of 17.78 g (33.8 mmol) of 3-(3,5-difluoro-2-methoxybenzyl)-N-(3,4-dimethoxybenzyl)-4-(3,4-dimethoxyphenyl)pyrrolidone in THF was dropwise added at 0° C. in a nitrogen atmosphere to 150 ml of a 1M solution of a borane/THF complex in THF. The mixture was heated under reflux for 2 hr and cooled, and 50 ml of a 6N hydrochloric acid solution was added thereto. The mixture was heated to 60° C. After stirring for 2 hr, THF was concentrated in vacuo and extracted twice with methylene chloride. The obtained organic phase was washed with a saline solution and dried over anhydrous sodium sulfate, and the solvent was distilled off in vacuo. The residue was subjected to silica gel column chromatography (ethyl acetate:n-hexane=4:1) to prepare 12.46 g (yield: 72%) of the intended product.

Provenance & Evidence