HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium thiocyanate → HCID 22400378, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium thiocyanate | HCID 15666 | — |
| Reactant | 1-(2-Chlorophenyl)methanamine--hydrogen chloride (1/1) | HCID 18670922 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22400378 | HCID 22400378 | 60% |
Reaction Steps
A solution of 2-chlorobenzylamine hydrochloride (41 g, 0.23 mol) and ammonium thiocyanate (19.28 g, 0.253 mol) in water (170 mL) was heated on the steam bath for 18 hours. This mixture was concentrated in vacuo, and the residue was taken up in toluene (1 L) and azeotroped with a Dean-Stark head. The residue was triturated with wet diethyl ether to provide 27.6 g (60%) of 1-(2-chlorophenyl)methyl thiourea. The product was recrystallized from ethanol; mp 120°-122° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444080 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-dc1c1824c1c0484bac39403a48e1faa8 |
| Source note | uspto-grants-1995_08 |