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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1757197Generated: November 1, 2026

Diethyl 2-benzylpropanedioate → 3-[2-n-Butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzylpropanoic Acid

https://huagongshe.com/reaction/1757197

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl 2-benzylpropanedioateHCID 69090—
ReactantMethyl 4-[(2-butyl-5-formyl-1H-imidazol-1-YL)methyl]benzoateHCID 10334966—
Product3-[2-n-Butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzylpropanoic AcidHCID 54294497—

Reaction Steps

The title compound was prepared following the procedure of Example 21 using 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde and diethyl benzylmalonate; mp 120°-124° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05444080
Source datasetuspto-grants-1995_08
ORD IDord-94c597c1b929410cb60e688e5c430ef1
Source noteuspto-grants-1995_08