3-Methylpentanoic acid → 3-Methylpentanoic anhydride

HRID 1757256Notes

Reaction equation

HRID 1757256 reaction equation
[CH3:1][CH:2]([CH2:7][CH3:8])[CH2:3][C:4]([OH:6])=[O:5].C(O[C:13](=[O:15])[CH3:14])(=O)C>>[CH3:1][CH:2]([CH2:7][CH3:8])[CH2:3][C:4]([O:6][C:13](=[O:15])[CH2:14][CH:2]([CH3:1])[CH2:3][CH3:4])=[O:5]

Participants

3

Reactant 2

HCID 77553-Methylpentanoic acidHCID 7918Acetic Anhydride

Product 1

HCID 467790543-Methylpentanoic anhydrideYield 97%

Procedure

3-Methylpentanoic acid anhydride was prepared from 6 moles of 3-methylpentanoic acid and 4.5 moles of acetic acid anhydride, by distilling acetic acid and the excess acetic acid anhydride from the reaction mixture at atmospheric pressure to a pot temperature of 220° C. Thereafter the desired anhydride was purified by distillation under reduced pressure. Yield: 97% of theory.

Workup

  1. distillationby distilling acetic acid
  2. customto a pot temperature of 220° C
  3. distillationThereafter the desired anhydride was purified by distillation under reduced pressure

Sources & evidence

ORD record
ord-6f9b9986d8ee4edbae729bd88a9c6fe0
Source dataset
uspto-grants-1995_08
Patent number
US05444162

Reaction notes

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