HCID 10251829, compound → HCID 67689610, compound

Participants

Reaction Steps

(Example 4): 4'-[(2-Butylquinolin-4-yloxy)methyl]biphenyl-2-carboxylic acid, m.p. 148° C.; NMR (d6 -DMSO): 0.93(t,3H), 1,38(m,2H), 1.8(m,2H), 2.95(t,2H), 5.5(s,2H), 7.25(s,1H), 7.33-7.68(complex m,8H), 7.7-7.85(m,2H), 7.98(d,1H), 8.2(d,1H); mass spectrum (-ve FAB, DMSO/GLY): 410 (M-H)-, 200; microanalysis found: C,77.1; H,6.1; N,3.1%; C27H25NO3.0.5H2O requires: C,77.1; H,6.2; N,3.3%; starting from methyl 4'-[(2-butylquinolin-4-yloxy)methyl]biphenyl-2-carboxylate obtained as viscous oil; NMR: 0.97(t,3H), 1.45(m,2H), 1.78(m,2H), 2.94(t,2H), 3.68(s,3H), 5.35(s,2H), 6.76(s,1H), 7.35-7.6(complex m,8H), 7.69(dt,1H), 7.88(dd,1H), 8.0 (d,1H), 8.25(dd,1H); mass spectrum (+ve CI): 426 (M+H)+, 225, 202; itself obtained from 2-butyl-4-quinolone using analogous procedures to those described in Example 1.

Provenance & Evidence