反应详情

To a solution of Leu-DTrp-βAla-OEt.TFA (40.6 mg) obtained in Example 51-(1) in chloroform (2 ml) were added TEA (20 μl) and phenyl isocyanate (15 μl) at room temperature under nitrogen. The reaction mixture was stirred for 1 h, and concentrated under reduced pressure. The residue was purified by dry column flash chromatography (Merck, Kieselgel 60) with chloroform/methanol=10/1 for elution to give the product (39.6 mg).

1. concentrationconcentrated under reduced pressure
2. customThe residue was purified
3. dry with materialby dry column flash chromatography (Merck, Kieselgel 60) with chloroform/methanol=10/1
4. washfor elution