HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1757341Generated: November 1, 2026
Bromoethene → 5-Ethenyl-1,2,3-trifluorobenzene
https://huagongshe.com/reaction/1757341
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromoethene | HCID 11641 | — |
| Reactant | 1-Bromo-3,4,5-trifluorobenzene | HCID 611409 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Catalyst | Nickel Dichloride | HCID 24385 | — |
| Catalyst | Zinc bromide | HCID 10421208 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Ethenyl-1,2,3-trifluorobenzene | HCID 15217121 | — |
Reaction Steps
A mixture of 1 mol of 3,4,5-trifluorobromobenzene and 3 l of THF is admixed at -70° C. with 1 mol of BuLi. Subsequently, a mixture of 0.5 mol of zinc bromide in 1 l of THF is added to the reaction mixture, and this mixture is stirred for 30 minutes at -65° C. Then 1 mol of vinyl bromide and 0.022 mol of nickel(II) chloride/TPP is added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05445764 |
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| Source dataset | uspto-grants-1995_08 |
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| ORD ID | ord-ae280176e84e4338bb2ad0ef6dbd4031 |
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| Source note | uspto-grants-1995_08 |
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