4-Tert-butyldiphenylsilyloxybenzeneboronic acid → 5-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoropyridine

HRID 1757365Notes

Reaction equation

HRID 1757365 reaction equation
Br[C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.[Si:10]([O:27][C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Br:9][C:5]1[CH:6]=[C:7]([F:8])[C:2]([C:31]2[CH:30]=[CH:29][C:28]([O:27][Si:10]([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:33][CH:32]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 218072914-Tert-butyldiphenylsilyloxybenzeneboronic acidHCID 224128322,5-Dibromo-3-fluoropyridine

Product 1

HCID 193875405-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoropyridine

Procedure

2,5-dibromo-3-fluoropyridine and 4-tert-butyldiphenylsilyloxybenzeneboronic acid are reacted analogously to Example 1 to give 5-bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoropyridine. ##STR31##

Sources & evidence

ORD record
ord-206c60969cd84d64a4895fd9d774e494
Source dataset
uspto-grants-1995_08
Patent number
US05445763

Reaction notes

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