Sodium Chloride → HCID 135815019, compound

Participants

Reaction Steps

4.30 g (8.00 mmol) of 2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-octyloxypyridine are stirred for 2 hours at room temperature with 16 ml of a 1-molar tetrabutylammonium fluoride solution in tetrahydrofuran in 50 ml of tetrahydrofuran. Aqueous sodium chloride solution is then added, the reaction mixture is extracted with ether, and the ether phase is washed with aqueous sodium chloride solution, dried over sodium sulfate, evaporated to dryness and purified by chromatography (silica gel/hexane: ethyl acetate 8:2), giving 2.16 g of 3-fluoro-2-(4-hydroxyphenyl)-5-octyloxypyridine. ##STR33##

Provenance & Evidence