2,5-Dibromo-3-fluoropyridine → HCID 178444297, compound

HRID 1757368Notes

Reaction equation

HRID 1757368 reaction equation
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].Br[C:22]1[C:27]([F:28])=[CH:26][C:25]([Br:29])=[CH:24][N:23]=1>>[Br:29][C:25]1[CH:26]=[C:27]([F:28])[C:22]([C:15]2[CH:14]=[CH:13][C:12]([C@H:9]3[CH2:10][CH2:11][C@H:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:7][CH2:8]3)=[CH:17][CH:16]=2)=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 224128322,5-Dibromo-3-fluoropyridineHCID 178444242HCID 178444242, compound

Product 1

HCID 178444297HCID 178444297, compound

Procedure

4-(trans-4-pentylcyclohexyl)benzeneboronic acid and 2,5-dibromo-3-fluoropyridine are reacted analogously to Example 1 to give 5-bromo-3-fluoro-2-[4-(trans-4-pentylcyclohexyl)phenyl]pyridine. ##STR36##

Sources & evidence

ORD record
ord-a8b8d1fce3e248c0859fbea67efd619f
Source dataset
uspto-grants-1995_08
Patent number
US05445763

Reaction notes

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