Trifluoroacetic acid → epsilon-(Benzyloxycarbonyl)-L-lysine

Participants

Reaction Steps

The 7,2 g of 1j were dissolved in 30 ml of dichloromethane and 15 ml of trifluoroacetic acid were added. The Boc group was immediately removed. After concentration, adding of ether and washing with NaHCO3, the organic phase was dried and concentrated. The Lys(Z) [C(O)NH(CH2)10CH3 ][NH2 ] formed was allowed to reactwith C8F17CH2CH2CO2H (7,6 g, 1,34.10-2 mole); 2.7 g of DCC (1.34.10-2 mole) and 100 mg of HOBT. The peptidiccoupling was carried out in dimethylformamide (DMF). After 24 h the DCU wasfiltered and the product was crystallized.

Provenance & Evidence