Bromomethyl 4-methoxyphenyl ketone → HCID 23371609, compound

HRID 1757391Notes

Reaction equation

HRID 1757391 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH2:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=2)=[CH:3][CH:2]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][Br:25])=[O:23])=[CH:18][CH:17]=1>C(O)C>[Br-:25].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][N+:1]2[CH:6]=[CH:5][C:4]([C:7]3[CH2:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=3)=[CH:3][CH:2]=2)=[O:23])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 127640636-(Pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 23371609HCID 23371609, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4,5-Dihydro-6-(4-pyridyl)-pyridazin-3(2H)-one (175 mg, 1 mmol) and 4'-methoxyphenacyl bromide (252 mg, 1.1 mmol) were dissolved in absolute ethanol (5 ml), refluxed for two hours and then stirred at room temperature overnight. The resulting precipitate was collected by filtration and washed with absolute ethanol to obtain the titled compound (350 mg) as brown columns.

Workup

  1. temperaturerefluxed for two hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with absolute ethanol

Sources & evidence

ORD record
ord-f4805730aa814a2f90de20c0f551532d
Source dataset
uspto-grants-1995_08
Patent number
US05446042

Reaction notes

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