Bromomethyl 4-methoxyphenyl ketone → HCID 178491495, compound

HRID 1757392Notes

Reaction equation

HRID 1757392 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:12][CH2:11][C:10](=[O:13])[NH:9][N:8]=2)=[CH:3][CH:2]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][Br:25])=[O:23])=[CH:18][CH:17]=1>C(O)C>[Br-:25].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][N+:1]2[CH:2]=[CH:3][C:4]([C:7]3[NH:12][CH2:11][C:10](=[O:13])[NH:9][N:8]=3)=[CH:5][CH:6]=2)=[O:23])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 178516760HCID 178516760, compound

Product 1

HCID 178491495HCID 178491495, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4,5-Dihydro-3-(4-pyridyl)-1,2,4-triazin-6(1H)-one (176 mg, 1 mmol) and 4'-methoxyphenacyl bromide (252 mg, 1.1 mmol) were dissolved in absolute ethanol (5 ml), refluxed for two hours and then stirred at room temperature for one day. The resulting precipitate was collected by filtration and washed with absolute ethanol to obtain the titled compound (374 mg) as yellow-brown powder.

Workup

  1. temperaturerefluxed for two hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with absolute ethanol

Sources & evidence

ORD record
ord-5b81f8ec1f9f4dc18bdd8ea9caeca36e
Source dataset
uspto-grants-1995_08
Patent number
US05446042

Reaction notes

Loading…