HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-3-yl)pyridine → 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-3-yl)pyridine | HCID 3613651 | — |
| Reactant | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 11055142 | — |
| Product | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid | HCID 15288440 | 82% |
Reaction Steps
Starting from 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1.24 g, 4.4 retool) and 3-(3-pyrrolidinyl)pyridine, a procedure analogous to that given in Example 1 provided the title compound(1.43 g, 82%) as a light beige solid, mp 226°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446044 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-ad5cec53d17940d7a60b4709f998e927 |
| Source note | uspto-grants-1995_08 |