Pyrrolidine → HCID 19388011, compound

Participants

Reaction Steps

18.85 g (0.10 mol) of 4-chloro-1-(2-thienyl)butanone are run, over a periodof 30 min, into a solution, maintained at 100° C., of 18.5 ml (0.22 mol) of pyrrolidine in 35 ml of toluene, and the mixture is heated to reflux for 2 hours. The reaction medium is diluted with ethyl ether and the mixture is washed with water. The organic phase is extracted with 2N hydrochloric acid solution which, after alkalinisation with sodium hydroxide, is in turn extracted with ethyl ether. The organic phase is dried over dry sodium sulphate and treated with a solution of hydrogen chloride in isopropanol.

Provenance & Evidence