HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(4-fluorophenyl)-beta,delta-dihydroxy-2-(1-methylethyl)-N,N,4-triphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(2-((4R,6R)-6-(2-(diphenylamino)-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide | HCID 11125529 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(4-fluorophenyl)-beta,delta-dihydroxy-2-(1-methylethyl)-N,N,4-triphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanamide | HCID 19006358 | — |
Reaction Steps
(4R-cis)-1-[2-[6-[2- (diphenylamino) -2-oxoethyl]-2,2 -dimethyl- 1,3 -dioxan-4-yl ]ethyl ]-5-(4- fluorophenyl)-2-(1-methylethyl)- N,4-diphenyl-1H- pyrrole -3-carboxamide is dissolved in methanol (300 mL) and reacted by adding 1.0N hydrochloric acid (100 mL) and stirring for 12 hours at room temperature. The white crystalline solid [R-(R*,R*) ]-5- (4-fluorophenyl)-β,δ-dihydroxy-2-(1-methylethyl)-N,N,4-triphenyl-3-[(phenylamino) carbonyl]-1H-pyrrole- 1-heptanamide is isolated by filtration (mp 228.5°-232.9° C., uncorrected).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446054 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-d0d25598bc56420bbc8f3730fd3eb5e7 |
| Source note | uspto-grants-1995_08 |