HCID 15290082, compound → HCID 19388469, compound

HRID 1757530Notes

Reaction equation

HRID 1757530 reaction equation
[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[C:18]([O:22][CH3:23])[CH:17]=[CH:16][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([S:14][CH3:15])=[S:13])[CH2:8][CH2:7]1.[ClH:24].C(O)C>>[ClH:24].[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[C:18]([O:22][CH3:23])[CH:17]=[CH:16][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([S:14][CH3:15])=[S:13])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 15290082HCID 15290082, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 19388469HCID 19388469, compoundYield 87.8%

Procedure

To 1.6 g of methyl 4-(2,3,4-trimethoxybenzyl)-1-piperazinecarbodithioate was dropwise added under chilling with ice 9 ml of 1-N hydrochloric acid-ethanol. The mixture was then stirred for 3 hours at room temperature. Precipitated crystals were collected by filtration and washedwith ethanol to give 1.5 g of the desired hydrochloride as a white powder, m.p. 182°-184° C. (decomp.), yield 87.8%.

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration and washedwith ethanol

Sources & evidence

ORD record
ord-fbe9731d2c7645619f3af68bab781a6d
Source dataset
uspto-grants-1995_08
Patent number
US05446146

Reaction notes

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