HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 9806308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 10904659 | HCID 10904659 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 9806308 | HCID 9806308 | 57% |
Reaction Steps
A mixture of 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl]phenoxy)methyl]quinoline (0.367 g), methyl iodide (0.2 ml) and acetonitrile (7 ml) was stirred at ambient temperature for 16 hours. The precipitate was filtered off to give 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl]phenoxy)methyl]-1-methylquinolinium iodide (0.29 g) in 57% yield, m.p. 190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446165 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-6e251cf00f064bc9af51a1ab12f01443 |
| Source note | uspto-grants-1995_08 |