Dimethyl Sulfate → HCID 11005515, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of a toluene solution of 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydo-2H-pyran-4-yl]phenoxy)methyl]quinoline (8% w/v, 115 ml) and dimethyl sulphate (4.75 g) was heated to 60° C. and stirred at this temperature for 4 hours. The mixture wascooled to ambient temperature and the precipitate was filtered off, washed with toluene (30 ml) and dried to give 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl]phenoxy)methyl]-1-methylquinolinium methyl sulphate (10.7 g) in 87% yield.

Provenance & Evidence