HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Nitecapone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 3,4-Dihydroxy-5-nitrobenzaldehyde | HCID 5748957 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Nitecapone | HCID 5464105 | — |
Reaction Steps
A solution containing 1.83 g of 3,4-dihydroxy-5-nitrobenzaldehyde and 1.00 g of 2,4-pentanedione in 10 ml of tetrahydrofuran was saturated with gaseous hydrogen chloride. After standing over night at 5° C. the product was filtered and washed with ether. Yield 1.2 g (50%), m.p. 175°-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446194 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-e4a180a5b51f4b3fb83d5ee5846212c4 |
| Source note | uspto-grants-1995_08 |