HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3,4-Dihydroxy-5-nitrobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Methane | HCID 297 | — |
| Reactant | 5-Nitrovanillin | HCID 81134 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 3,4-Dihydroxy-5-nitrobenzaldehyde | HCID 5748957 | — |
Reaction Conditions
| Temperature | -10 °C |
|---|
Reaction Steps
A solution containing 8.0 kg of 5-nitrovanillin and 8.7 kg of acetic acid in 35 kg of conc. hydrobromic acid was refluxed for 20 h. 0.6 kg of charcoal was added and the mixture was filtered. 32 kg of water was added with stirring and the solution was cooled to -10° C. and stirring was continued for 2 h more. The crystalline product was filtered and washed with water. Yield 5.66 kg (80%), m.p. 135°-137° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446194 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-7a2642c5d67e4452a578e6a73287cfce |
| Source note | uspto-grants-1995_08 |