HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate | HCID 10860587 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane | HCID 9861019 | 99.5% |
Reaction Steps
A solution of 11.4 g of 3(S)-(benzyloxyformamido)-1-chloro-4-phenyl-2(S)-butanol in 300 ml of ethanol containing 2.24 g of potassium hydroxide was left to stand for 15 minutes. The solvent was removed by evaporation and the residue was partitioned between water and dichloromethane. Working-up gave 10.1 g of crude 3(S)-(benzyloxyformamido)-1,2(S)-epoxy-4-phenylbutane as an off-white solid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05446161 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-d426921a91524b63901cce371352ac45 |
| Source note | uspto-grants-1995_08 |