Ethylmorpholine → Benzyloxycarbonyl-asparagine

Participants

Reaction Steps

In a manner analogous to that described in Example 33, from 0.225 g of dicyclohexylcarbodiimide, 0.135 g of hydroxybenzotriazole, 0.115 g of N-ethylmorpholine, 0.38 g of N2 -[3(S)-amino-2(R)-hydroxy-4-Phenylbutyl]-N1 -benzyl-L-prolinamide and0.266 g of N-(benzyloxycarbonyl)-L-asparagine there was obtained 0.056 g ofN1 -benzyl-N2 -[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl] amino]-2(R)-hydroxy-4-phenylbutyl]-L-prolinamide as a white solid: MS: m/e616 [M+H]+.

Provenance & Evidence