Ethylmorpholine → Dicyclohexylcarbodiimide

Participants

Reaction Steps

In a manner analogous to that described in Example from 295 mg of N2 -[3(S) [[L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-L-prolinamide, 204 mg of 6-(benzyloxycarbonyl ) -2-naphthoic acid, 20 mg of hydroxybenzotriazole, 77 mg of N-ethylmorpholine and 151 mgof dicyclohexylcarbodiimide there were obtained, after chromatography on silica gel using System G for the elution, 340 mg of N2 -[3(S)-[[N-[6-(benzyloxycarbonyl)-2-naphthoyl]-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-L-prolinamide as an off-white solid from ethyl acetate/n-hexane: MS: m/e 736 [M+H]+.

Provenance & Evidence