N2 (benzyloxycarbonyl)-N1-tert.butyl-4(R)-hydroxy-L-prolinamide → N1-tert.butyl-4(R)-hydroxy-L-prolinamide

Participants

Reaction Steps

0.224 g of N2 -(benzyloxycarbonyl)-N1 -tert.butyl-4(R)-hydroxy-L-prolinamide was dissolved in 20 ml of ethanol and hydrogenated over 50 mg of 10% palladium-on-carbon at room temperatureand under atmospheric pressure for 2 hours. The catalyst was filtered off and the filtrate was evaporated to give 0.13 g of N1 -tert.butyl-4(R)-hydroxy-L-prolinamide which was used in the next step without further purification.

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