Sodium Hydroxide → HCID 131719115, compound

Participants

Reaction Steps

A solution of 0.73 g (1.02 mmol) of N-(2-methoxy-2-oxoethyl)-N-[3-[3-[4-(methylsulfinyl)phenoxy]propoxy]-5-(octadecyloxy)phenyl]glycine methyl ester and 0.68 ml (4.08 mmol) of 6N NaOH in 30 ml of methanol was stirred at reflux under argon for 4 hours. The methanol was removed at reduced pressure, the residue was acidified and the product was extracted with ethyl acetate. The dried extract was concentrated to a solid which was recrystallized from acetone-hexane to give 0.57 g (82% yield, mp 124°-126°) of N-(carboxymethyl)-N-[3-[3-[4-(methylsulfinyl)phenoxy]propoxy]-5-(octadecyloxy)phenyl glycine.

Provenance & Evidence