Ammonia → 6-Amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile

HRID 1757901Notes

Reaction equation

HRID 1757901 reaction equation
[NH3:1].[Cl:2][C:3]1[C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=[C:5](NCC)[N:4]=1.[CH:15]([NH2:18])([CH3:17])[CH3:16]>>[NH2:1][C:7]1[N:6]=[C:5]([NH:18][CH:15]([CH3:17])[CH3:16])[N:4]=[C:3]([Cl:2])[C:8]=1[C:9]#[N:10]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6363IsopropylamineHCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

Product 1

HCID 205102266-Amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile

Procedure

This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and aqueous ammonia for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from benzene to give 6-amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 162°-165°.

Workup

  1. customThis compound was prepared in the manner of Example XVII
  2. customThe reaction product was recrystallized from benzene

Sources & evidence

ORD record
ord-841a6010216a4ab38c2501ebd055c763
Source dataset
uspto-grants-1983_02
Patent number
USRE031136

Reaction notes

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