Acetic Anhydride → HCID 13025346, compound

Participants

Reaction Steps

2.2 g of 15α-hydroxy-18-methyl-11-methylene-4-estrene-3,17-dione is reacted in 10 ml of pyridine with 2.5 ml of acetic anhydride under argon at room temperature within 2 hours. The solution is introduced into ice/water. The thus-precipitated crude product is vacuum-filtered, dissolved in ethyl acetate, and dried. Chromatography of the crude product on silica gel with 0-20% acetone/hexane yields 1.7 g of 15α-acetoxy-18-methyl-11-methylene-4-estrene-3,17-dione, mp 176.3° C.

Provenance & Evidence