Formaldehyde → HCID 13712582, compound

Participants

Reaction Steps

To a solution of 1.1 g. (5 mmoles) of 2-acetyl-3-phenyl-tetrahydro-1,2,4-oxadiazin-5-one in 10 ml. of tetrahydrofurane 1 ml. of triethyl amine and 0.4 ml. of a 37% aqueous formaldehyde solution are added. The mixture is allowed to stand at room temperature overnight and is then evaporated to dryness. The residue is triturated with diethyl ether and the product is isolated by filtration. 1.16 g. (93%) of 2-acetyl-3-phenyl-4-hydroxymethyl-tetrahydro-1,2,4-oxadiazin-5-one are obtained, melting at 123° to 126° C. RfA =0.5.

Provenance & Evidence