Thionyl Chloride → HCID 13712584, compound

Participants

Reaction Conditions

Reaction Steps

0.5 g. (2 mmoles) of 2-acetyl-3-phenyl-4-hydroxymethyltetrahydro-1,2,4-oxadiazin-5-one are refluxed in 3 ml. of thionyl chloride for one hour. The solution is evaporated to dryness under reduced pressure. The residue is triturated with diethyl ether cooled to 0° C. and the product is filtered off and is subsequently recrystallized from a mixture of 2 ml. of chloroform and 6 ml. of n-hexane. 0.28 g. (53%) of 2-acetyl-3-phenyl-4-chloromethyl-tetrahydro-1,2,4-oxadiazin-5-one are obtained, melting at 171° to 172° C.; RfA =0.7.

Provenance & Evidence