Phosphorus sulfide (P2S5) → HCID 20059996, compound

Participants

Reaction Steps

A stirred mixture of 5.0 g of β-carbolin-3-carboxamide dissolved in 100 ml of dry pyridine and 5.0 g of phosphorus pentasulfide is boiled under reflux for 4 hours. The cooled reaction mixture is concentrated to about 25 ml in vacuo and poured into 1 liter of ice water. After adjusting the pH of the mixture to 8.5 with aqueous ammonia, a solid is filtered off, washed thoroughly with water and dried. The substance formed (3.2 g) is recrystallized from n-butyl alcohol to form β-carbolin-3-carbothioamide of a melting point of 274°-276° C.

Provenance & Evidence