反应详情

温度

0 °C

2.81 g of 6-cyano-4-methyl-β-carbolin-3-carboxylic acid ethyl ester is heated with 4.6 g of potassium hydroxide in 20 ml of ethylene glycol for 16 hours at 150° C. After cooling to 0° C., 10 ml of acetic acid is added dropwise. The mixture is diluted with 100 ml of water and, after saturation with sodium chloride, is extracted with ethyl acetate. The extracts are washed until neutral with saturated common salt solution, dried using sodium sulphate, filtered, and the solvent is distilled off in vacuo. The crude product is dissolved in 30 ml of 10% methanolic hydrochloric acid and boiled for 5 hours under reflux. After distilling off the solvent in vacuo, 20 ml of dilute aqueous ammonia are added and the mixture is extracted with ethyl acetate. After washing until neutral, drying and distilling off the solvent, the crude product is recrystallized from diisopropyl ether. 1.36 g of 4-methyl-β-carbolin-3,6-dicarboxylic acid dimethyl ester of melting point 199°-204° C. is obtained.

1. extractionafter saturation with sodium chloride, is extracted with ethyl acetate
2. washThe extracts are washed until neutral with saturated common salt solution
3. customdried
4. filtrationfiltered
5. distillationthe solvent is distilled off in vacuo
6. dissolutionThe crude product is dissolved in 30 ml of 10% methanolic hydrochloric acid
7. temperatureunder reflux
8. distillationAfter distilling off the solvent in vacuo, 20 ml of dilute aqueous ammonia
9. additionare added
10. extractionthe mixture is extracted with ethyl acetate
11. washAfter washing until neutral,
12. customdrying
13. distillationdistilling off the solvent
14. customthe crude product is recrystallized from diisopropyl ether