3-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid → HCID 131712001, compound

HRID 1758055Notes

Reaction equation

HRID 1758055 reaction equation
[O:1]1[C:6]([C:7](=[N:11][O:12][CH3:13])[C:8]([OH:10])=O)=[CH:5][S:4][CH2:3][CH2:2]1.[NH2:14][CH:15]1[C:30](=[O:31])[N:17]2[C:18]([C:27]([OH:29])=[O:28])=[C:19]([CH2:22][O:23][C:24](=[O:26])[NH2:25])[CH2:20][S:21][C@H:16]12>>[O:1]1[C:6]([C:7](=[N:11][O:12][CH3:13])[C:8]([NH:14][CH:15]2[C:30](=[O:31])[N:17]3[C:18]([C:27]([OH:29])=[O:28])=[C:19]([CH2:22][O:23][C:24](=[O:26])[NH2:25])[CH2:20][S:21][C@H:16]23)=[O:10])=[CH:5][S:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 127847593-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acidHCID 53841578HCID 53841578, compound

Product 1

HCID 131712001HCID 131712001, compound

Procedure

2-(2,3-Dihydro-1,4-oxathiin-6-yl)-2-methoxyiminoacetic acid (syn isomer, 0.508 g.) was allowed to react with 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (0.82 g.) in a similar manner to that of Example 1 to give the captioned compound (0.85 g.), pale yellow powder, mp. 175° to 180° C. (dec.).

Workup

  1. customto give the captioned compound (0.85 g.), pale yellow powder, mp. 175° to 180° C. (dec.)

Sources & evidence

ORD record
ord-899087ea05ee4cfaabba84cff5881ba7
Source dataset
uspto-grants-1983_02
Patent number
US04371531

Reaction notes

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