7-Amino-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylicacid → HCID 131712003, compound

HRID 1758057Notes

Reaction equation

HRID 1758057 reaction equation
[CH:1]([N:3]1[C:8]([C:9](=[N:13][O:14][CH3:15])[C:10]([OH:12])=O)=[CH:7][S:6][CH2:5][CH2:4]1)=[O:2].[NH2:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]3[N:30]([CH3:31])[N:29]=[N:28][N:27]=3)[CH2:22][S:23][C@H:18]12>>[CH:1]([N:3]1[C:8]([C:9](=[N:13][O:14][CH3:15])[C:10]([NH:16][CH:17]2[C:35](=[O:36])[N:19]3[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]4[N:30]([CH3:31])[N:29]=[N:28][N:27]=4)[CH2:22][S:23][C@H:18]23)=[O:12])=[CH:7][S:6][CH2:5][CH2:4]1)=[O:2]

Participants

3

Reactant 2

HCID 130208137-Amino-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylicacidHCID 54291157HCID 54291157, compound

Product 1

HCID 131712003HCID 131712003, compound

Procedure

2-(4-Formyl-(2,3-dihydro-4H-1,4-thiazin-5-yl)-2-methoxyiminoacetic acid (syn isomer, 2.3 g.) was allowed to react with 7-amino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (3.3 g.) in a similar manner to that of Example 1 to give the captioned compound (2.5 g.), pale yellow powder, mp. 150° to 155° C. (dec.).

Workup

  1. customto give the captioned compound (2.5 g.), pale yellow powder, mp. 150° to 155° C. (dec.)

Sources & evidence

ORD record
ord-d72fbf0db14544f8ba2e4106cdd85508
Source dataset
uspto-grants-1983_02
Patent number
US04371531

Reaction notes

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