7-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acid → HCID 131712005, compound

HRID 1758060Notes

Reaction equation

HRID 1758060 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][CH:3]=[C:2]1[C:11](=[N:15][O:16][CH3:17])[C:12]([OH:14])=O.[NH2:18][CH:19]1[C:36](=[O:37])[N:21]2[C:22]([C:33]([OH:35])=[O:34])=[C:23]([CH2:26][S:27][C:28]3[S:29][CH:30]=[N:31][N:32]=3)[CH2:24][S:25][C@H:20]12>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][CH:3]=[C:2]1[C:11](=[N:15][O:16][CH3:17])[C:12]([NH:18][CH:19]1[C:36](=[O:37])[N:21]2[C:22]([C:33]([OH:35])=[O:34])=[C:23]([CH2:26][S:27][C:28]3[S:29][CH:30]=[N:31][N:32]=3)[CH2:24][S:25][C@H:20]12)=[O:14]

Participants

3

Reactant 2

HCID 128891877-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acidHCID 54473894HCID 54473894, compound

Product 1

HCID 131712005HCID 131712005, compound

Procedure

2-(1,4-Benzoxathiin-2-yl)-2-methoxyiminoacetic acid (syn isomer, 0.85 g.) was allowed to react with 7-amino-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (1.09 g.) in a similar manner to that of Example 1 to give the captioned compound (1.50 g.), yellow powder, mp. 157° to 161° C. (dec.).

Workup

  1. customto give the captioned compound (1.50 g.), yellow powder, mp. 157° to 161° C. (dec.)

Sources & evidence

ORD record
ord-a7b453b82f2940ad8d985d451b5afd51
Source dataset
uspto-grants-1983_02
Patent number
US04371531

Reaction notes

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