Dimethyl Sulfate → HCID 12783077, compound

HRID 1758097Notes

Reaction equation

HRID 1758097 reaction equation
[OH-].[Na+].[CH3:3][C:4]([CH3:10])([C:7](=[O:9])[CH3:8])[CH2:5][OH:6].S(OC)(O[CH3:15])(=O)=O>O>[CH3:3][C:4]([CH3:10])([C:7](=[O:9])[CH3:8])[CH2:5][O:6][CH3:15]

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 111943184-Hydroxy-3,3-dimethylbutan-2-one

Product 1

HCID 12783077HCID 12783077, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

80 g (2 moles) of sodium hydroxide, dissolved in 100 ml of water, were added dropwise to 174 g (1.5 moles) of 2,2-dimethyl-1-hydroxy-butan-3-one (for the preparation, see Example 2a) and 150 ml (2 moles) of dimethyl sulphate at 40° C. (exothermic, slight cooling). After the addition, the mixture was subsequently stirred at 40° C. for 15 hours and the 2,2-dimethyl-1-methoxy-butan-3-one formed was distilled by means of steam. The aqueous phase was saturated with sodium chloride and the oily constituent was separated off and rectified under reduced pressure. 123.8 g (63% of theory) of 2,2-dimethyl-1-methoxy-butan-3-one of boiling point 48°-62° C./5-8 mm Hg were obtained.

Workup

  1. customfor the preparation
  2. customat 40° C.
  3. temperature(exothermic, slight cooling)
  4. additionAfter the addition

Sources & evidence

ORD record
ord-04079daf213145e49e8cf18f56633281
Source dataset
uspto-grants-1983_02
Patent number
US04371708

Reaction notes

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