2-Methyl-2-butanol → HCID 20510601, compound

Participants

Reaction Steps

To 300 ml of t-pentyl alcohol were added potassium t-pentoxide (prepared from 5.0 g of metallic potassium) and 6.6 g of 2,2-bis{4-[2-hydroxy-3-(4-hydroxy-2,2,6,6-tetramethylpiperidino)propoxy]-phenyl}propane (obtained as described in Example 1); the mixture was refluxed for 2 hours. The reaction mixture was cooled to ambient temperature and there were added 10.0 g of n-butyl bromide. The mixture was heated at 50°-60° C. for 15 hours. After completion of the reaction, the reaction mixture was condensed by evaporation under reduced pressure and the residue was extracted with benzene. The extract was washed with water and dried over anhydrous potassium carbonate. The solvent was removed from the dried solution by evaporation under reduced pressure and the resulting residue was purified by column chromatography through silica gel eluted with a 2:5 by volume mixture of ethyl acetate and benzene. The desired Compound No. 30 was obtained in the form of a colourless viscous oil having an Rf value of 0.68 on thin-layer chromatography on silica gel developed with a 8:1:1:1 by volume mixture of ethyl acetate, benzene, ethanol and triethylamine.

Provenance & Evidence