Methyl trifluoromethyl ketone → HCID 20509968, compound

HRID 1758252Notes

Reaction equation

HRID 1758252 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][N:11](C(OCC)C)[C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[F:25][C:26]([F:31])([F:30])[C:27]([CH3:29])=[O:28]>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]2[N:11]=[C:10]([C:27]([CH3:29])([C:26]([F:31])([F:30])[F:25])[OH:28])[NH:9][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 9871Methyl trifluoromethyl ketoneHCID 13127256HCID 13127256, compound

Product 1

HCID 20509968HCID 20509968, compound

Procedure

By the procedure described in the second paragraph of Example 1, 4,5-bis(4-fluorophenyl)-1-(α-ethoxyethyl)imidazole was reacted with 1,1,1-trifluoroacetone to give 4,5-bis(4-fluorophenyl)-α-methyl-α-trifluoromethyl-1H-imidazole-2-methanol, m.p. 191°-192°. The infrared and NMR spectra were consistent with the assigned structure.

Sources & evidence

ORD record
ord-5de6a14baa774e8cbdf44305b8296f0c
Source dataset
uspto-grants-1983_02
Patent number
US04372964

Reaction notes

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