Carbon Tetrachloride → HCID 20509989, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of triphenylphosphine (8.8 g, 0.033 mol) and carbon tetrachloride (19.5 cm3) was stirred at 60° C. for 2 hr. A solution of 6-methylbenzofuran-3(2H)-one (5.0 g, 0.034 mol) in toluene (50 cm3) was added dropwise and the mixture was stirred at 115° C. for 18 hr. The cooled mixture was filtered and the solvent was removed from the filtrate. The residue was extracted with hot petroleum ether (b.p. 60°-80° C.). The extract was chromatographed on silica using petroleum ether (b.p. 60°-80° C.) as the eluant to give 3-chloro-6-methylbenzofuran (2.3 g, 0.014 mol, 40.0%) RF 0.51.

Provenance & Evidence