Bromine → HCID 20509994, compound

Participants

Reaction Conditions

Reaction Steps

A solution of bromine (8.4 g, 0.0525 mol) in carbon disulphide (75 cm3) was added dropwise to a stirred solution of 6-methylbenzofuran (7.64 g, 0.0516 mol) in carbon disulphide (125 cm3) at below 10° C. The solvent was removed and the residue was heated at 150° C. for 1.5 hr. under reduced pressure. The residue was subjected to column chromatography on silica using petroleum ether (b.p. 60°-80° C.) as the eluant. The solvent was removed from the appropriate fractions to give 2-bromo-6-methylbenzofuran (11.0 g, 0.051 mol; 98.2%) RF 0.80.

Provenance & Evidence