Bromide ion → HCID 54049198, compound

Participants

Reaction Steps

A solution of bromide (0.90 g, 5.7×10-3 mol) and 7-chloro-α-isopropylbenzofuran-4-acetic acid (1.44 g, 5.7×10-3 mol) in tetrachloromethane (50 cm3) was heated to reflux for 2 hr. The solvent was removed and the residue was subjected to column chromatography on silica using ethyl acetate as the eluant. The appropriate fractions were combined and the solvent was removed to give 2-bromo-7-chloro-α-isopropylbenzofuran-4-acetic acid (1.50 g, 4.5×10-3 mol, 79.5%).

Provenance & Evidence