Potassium Carbonate → HCID 13061982, compound

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Reaction Steps

2-Pyridyl 3-chloropropyl sulfone (2.2 g) and 1-methyl-5-mercapto-1,2,3,4-tetrazole (1.2 g) are dissolved in acetone (50 ml). Potassium carbonate (1.4 g) is added to the solution and the mixture is refluxed for 5 hours. Acetone is distilled off and water is added to the residue. The mixture is extracted with chloroform. The chloroform solution is washed with saturated aqueous sodium chloride and dried over magnesium sulfate. Chloroform is distilled off and the residue is purified by column chromatography (Kieselgel 60). The column is eluted with chloroform-methanol and the product is recrystallized from ethanol to obtain 3-(1-methyl-1,2,3,4-tetrazol-5-yl)thiopropyl 2-pyridyl sulfone (1 g) as colorless prisms, m.p. 98.5°-101° C.

Provenance & Evidence