Potassium Carbonate → HCID 13091634, compound

Participants

Reaction Steps

1-Methyl-5-mercapto-1,2,3,4-tetrazole (1.2 g), potassium carbonate (2.1 g) and 3-chloropropyl 4-ethylphenyl ketone (3.2 g) are added to acetone (50 ml) and the mixture is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off. The filtrate is concentrated under reduced pressure and the residue is purified by cilica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) and the product is recrystallized from hexane-ether to obtain 1-methyl-5-[3-(4-ethylbenzoyl)propyl]thio-1,2,3,4-tetrazole (yield 49%) as colorless needles, m.p. 68°-69° C.

Provenance & Evidence