Methyl isothiocyanate → HCID 13138424, compound

Participants

Reaction Steps

3-(1-Methyl-1,2,3,4-tetrazol-5-yl)thiopropylamine (1.5 g) is dissolved in ethanol (5 ml), and thereto is added dropwise a solution of methyl isothiocyanate (0.8 g) in ethanol (5 ml) with stirring under ice-cooling, and the mixture is refluxed for 1 hour. Ethanol is distilled off, and then the residue is purified by column chromatography (Kieselgel 60), followed by eluting with chloroform-methanol (50:1) to give 1-[3-(1-methyl-1,2,3,4-tetrazol-5-yl)thiopropyl]-3-methylthiourea (0.7 g) which is recrystallized from ethanol-ligroin, pale yellow granules, m.p. 99°-101° C.

Provenance & Evidence